Adherence & Retention
Depression, Alcohol Use and Adherence to ART in Africa: A Systematic Review by Nakimuli-Mpungu et al. AIDS & Behavior 2011
Dear GHD Colleagues:
I thought this recently (Nov 25th) e-published manuscript ahead of print looking at depression, alcohol use and ART adherence from our collaborative research group and led by Nakimuli-Mpungu E et al. may be of interest to some of you (abstract below).
This work was also presented last May at the IAPAC-NIMH International Conference on HIV Treatment and Prevention Adherence in Miami (Oral Abstract # 70490).
Best Regards,
Jean
ABSTRACT
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Abstract
This study evaluated estimates of depression symptoms, major depression, alcohol use or disorders and their association with ART adherence in sub-Saharan Africa. Studies published between January 1, 2006 and July 31, 2011 that documented rates of these mental health problems were identified through electronic databases. A pooled analysis of 23 studies reporting rates of depression symptoms and six studies reporting rates of major depression indicated a pooled estimate of 31.2% (95% CI 25.5–38.2%, Tau2 = 0.23) and 18% (95% CI 12.3–25.8%, Tau2 = 0.19) respectively. Few studies reported rates of alcohol use or disorders, and so we did not pool their estimates. Likelihood of achieving good adherence was 55% lower among those with depression symptoms compared to those without (pooled OR = 0.45 (95% CI 0.31–0.66, Tau2 = 0.20, P value = 0.000). Interventions to improve mental health of HIV-positive individuals and to support adherence are desperately needed in sub-Saharan Africa.
AIDS & Behavior Weblink:
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http://www.springerlink.com/content/1839156555306637/fulltext.html
