Adherence & Retention
Do Benefits of Earlier Antiretroviral Treatment Initiation Outweigh Harms for Individuals at Risk for Poor Adherence?
Clinicians may defer antiretroviral treatment for patients with suboptimal adherence. The authors of this study used a validated computer simulation of HIV disease progression to compare alternative treatment thresholds for patients with suboptimal adherence. Earlier treatment increased life expectancy across a wide adherence range (50%–100% of doses taken). Delaying treatment for patients with suboptimal adherence may not always be appropriate.
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