Adherence & Retention
Fundamentals of Antiretroviral Therapy
Excerpt:
The use of antiretroviral therapy (ART) in developed countries has successfully reduced AIDS-related mortality by 90% and has significantly reduced opportunistic infections and other consequences of HIV disease. [1, 2] In developing countries, combination ART has transformed the AIDS epidemic, with significant decreases in mortality, hospitalizations, and incidence of opportunistic infections. [3] Yet in sub-Saharan Africa, which accounts for more than 70% of the global burden of HIV/AIDS, only about 25% of the six million people who require ART have access to treatment. [4] This is despite continued calls to get more people on treatment, including initiatives such as the “3 by 5” campaign of the World Health Organization (WHO) and Joint United Nations Program on HIV/AIDS (UNAIDS), and the Group of Eight (G8) pledge to provide “universal access to ART.”
1. Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1999;338:853-860.
Full text (PDF): http://www.nejm.org/doi/pdf/10.1056/NEJM199803263381301
2. S Stern JA, Hernan MA, Ledergerber B, et al. Long effectiveness of potent antiretroviral therapy in preventing AI DS and death: a prospective cohort study. Lancet. 2005;366:378-384.
Full text (HTML and PDF) to signed-in users: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67022-5/ful...
3. L Laurent C, Diakhate N, Ngom Gueye NF , et al. The Senegalese government’s highly active antiretroviral therapy initiative: an 18-month follow up study. AIDS. 2002;16:1363-1370.
Full text (HTML and PDF): http://journals.lww.com/aidsonline/Fulltext/2002/07050/The_Senegalese_governm...
4. World Health Organization (WHO). Progress on global access to HIV antiretroviral therapy: a report on “3 by 5” and beyond. Geneva, Switzerland: WHO and Joint United Nations Program on HIV /AI DS (UNAI DS); 2006.
PDF Report (HTML and PDF) – Available in English, Francais, Espanol, Russian http://www.who.int/3by5/publications/progressreport/en/
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