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MDR-TB Treatment & Prevention

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Principles of out-patients MDR-TB Treatment & Management

Started by Salmaan Keshavjee, MD, PhD on 26 Sep 2008

This presentation was given during the Istanbul training last April.

How to respond to the epidemic? Several cases presented with lessons learned:
- Peru
- Lesotho
- Tomsk

It is possible to successfully treat TB and MDR TB in an ambulatory setting.

Directly Observed Therapy (DOT) is more than just observation:

- It is the direct observation of patients taking their medicines
- It is the documentation of the visit
- It allows a daily rechecking of the patient medications
- It is the control of side effects
- It involves home visits if patients do not come to the clinic
- It involves looking for patients who are non-adherent or are defaulting
- DOT is an extension of the clinic into the patients community
- The system of DOT can be used to find programmatic solutions to patient barriers
- Food assistance for patients
- Choice of treatment site
- Improved side effect management (provision of ancillary medications)
- Improvement of working hours at medical facilities to make it more convenient for patients
- Treatment at home for patients who are unable to ambulate or who live too far
- Use of volunteers (e.g. neighbors) for DOT
- Rapid search for non-adherent patients and defaulters
- The use of enablers and incentives

Incentives for patients:

- Improved nutrition in the hospital with snacks
- Hot meals at the day hospital
- Food packets monthly for adherent patients
- Travel vouchers (government provided)
- Small gifts for adherence
- Help with passports, access to pensions, etc.

Incentives for staff:

- Hot meals at the day hospital
- Food packets monthly for rural health workers and nurses

Attached resource:

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