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Summary Points:

* The World Health Organization calls for massive scale-up of programmatic management of drug-resistant tuberculosis in resource-limited settings.

* Several technical and operational barriers impede the achievement of this scale-up.

* A research agenda, developed by the Stop TB Partnership, identifies the most important barriers and prioritizes the research questions to be addressed in order to overcome these barriers.

* Research priorities include: new and improved tools for drug resistance testing; clinical trials of simplified and shorter second-line treatment regimens; new and improved strategies for diagnosis of drug-resistant tuberculosis, treatment adherence, and infection control; understanding of the geographic variations in occurrence of drug resistance; and clinical trials of prophylactic treatment of contacts of patients with drug-resistant tuberculosis.

Attached resource:

Link leads to: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050150&ct=1

Summary: Summary Points:

* The World Health Organization calls for massive scale-up of programmatic management of drug-resistant tuberculosis in resource-limited settings.

* Several technical and operational barriers impede the achievement of this scale-up.

* A research agenda, developed by the Stop TB Partnership, identifies the most important barriers and prioritizes the research questions to be addressed in order to overcome these barriers.

* Research priorities include: new and improved tools for drug resistance testing; clinical trials of simplified and shorter second-line treatment regimens; new and improved strategies for diagnosis of drug-resistant tuberculosis, treatment adherence, and infection control; understanding of the geographic variations in occurrence of drug resistance; and clinical trials of prophylactic treatment of contacts of patients with drug-resistant tuberculosis.

Source: PLoS Medicine

Publication Date: July 8, 2008

Language: English

Keywords: Publications & Research

 
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