MDR-TB Treatment & Prevention
Xpert MTB/RIF Rapid Molecular Detection of TB and Rifampin Resistance_NEJM
Rapid Molecular Detection of Tuberculosis and Rifampin Resistance. N Engl J Med 2010; 363:1005-1015.
This article presents a clinical study to evaluate the performance of the Xpert MTB/RIF. The study was designed by the Foundation for Innovative New Diagnostics. It evaluated the sputum of 1730 patients from trial sites in Peru, Azerbaijan, South Africa, and India to determine both the sensitivity and specificity of the test compared to the current gold standards. A single direct Xpert MTB/RIF test successfully identified MTB with a sensitivity of 98.2% in smear-positive culture-confirmed cases and 72.5% in smear-negative culture-confirmed cases. The specificity was 99.2%. Resistance and sensitivity to Rifampicin was correctly identified in 97.6% and 98.1% of cases, respectively. The accurate detection of MTB in only 100 minutes could translate into improved care for patients with tuberculosis.
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Xpert MTB/RIF Rapid Molecular Detection of TB and Rifampin Resistance_NEJM (external URL) Link leads to: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947799/?tool=pubmed
Summary: Rapid Molecular Detection of Tuberculosis and Rifampin Resistance. N Engl J Med 2010; 363:1005-1015.
This article presents a clinical study to evaluate the performance of the Xpert MTB/RIF. The study was designed by the Foundation for Innovative New Diagnostics. It evaluated the sputum of 1730 patients from trial sites in Peru, Azerbaijan, South Africa, and India to determine both the sensitivity and specificity of the test compared to the current gold standards. A single direct Xpert MTB/RIF test successfully identified MTB with a sensitivity of 98.2% in smear-positive culture-confirmed cases and 72.5% in smear-negative culture-confirmed cases. The specificity was 99.2%. Resistance and sensitivity to Rifampicin was correctly identified in 97.6% and 98.1% of cases, respectively. The accurate detection of MTB in only 100 minutes could translate into improved care for patients with tuberculosis.Source: New England Journal of Medicine - NEJM
Publication Date: September 9, 2010
Language: English
Keywords: diagnostics, Laboratory, Publications & Research
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