In this community, professionals share information regarding the clinical, programmatic and community-oriented aspects of early diagnosis, treatment and prevention of multi-drug-resistant tuberculosis (MDR-TB). Members also use this forum to promote universal access to quality care for MDR-TB.
Was this the initial diagnosis? Was sputum sampling done at the same time, ie same day/month, before or during treatment? If pt was on treatment before, which regime? Xpert results are telling us about presence of genes of an organism that is present or was present. Upon using susceptible drugs, ... read more
Gene expert is molecular and gold standard for us in Tanzania we have had multiple cases where our sputum cultures and even Bal cultures are negative but gene expert positive.in your case if it's negative you can confidently asses clinically and give the patient good follow-up so as to repeat ... read more
Recently we had a case from India of a patient on standard MDR TB regimen (Z, Cm, Lfx, Pto, Cs) who developed severe thrombocytopenia at 5 months of treatment initiation. Which could be the most likely drug? I would say Cm followed by Lfx. Any other suggestions or experiences? read more
Dear Ranjan, The correct sample & sample volumes are as follow: 500 ul of decontaminated sediment not sputum (500 ul of decontaminated specimen is prepared by concentration of 3-5 ml of sputum sample by NALC-NAOH method). About 1000ul of liquid culture; actually 1 ml of liquid culture; that showed positive ... read more
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