In this community, professionals share information regarding the clinical, programmatic and community-oriented aspects of early diagnosis, treatment and prevention of multi-drug-resistant tuberculosis (MDR-TB). Members also use this forum to promote universal access to quality care for MDR-TB.

Community moderators

Masoud Dara, MD
WHO Europe - EURO
Christopher Gilpin, PhD, MPH
World Health Organization - WHO
Dylan Tierney
Brigham and Women's Hospital, Division of Global Health Equity

Recent community activity

INCONSISTENT XPERT AND CULTURE RESULTS

Musarurwa Kwaramba replied

Was this the initial diagnosis? Was sputum sampling done at the same time, ie same day/month, before or during treatment? If pt was on treatment before, which regime? Xpert results are telling us about presence of genes of an organism that is present or was present. Upon using susceptible drugs, ... read more

Updated: 28 Feb, 2017
Recommendations: 3
Replies: 10

Re: INCONSISTENT XPERT AND CULTURE RESULTS

dr.hanifa mbithe replied

Gene expert is molecular and gold standard for us in Tanzania we have had multiple cases where our sputum cultures and even Bal cultures are negative but gene expert positive.in your case if it's negative you can confidently asses clinically and give the patient good follow-up so as to repeat ... read more

Updated: 28 Feb, 2017
Reply: 1

Thrombocytopenia in a patient on standard MDR TB regimen

by Animesh Sinha

Recently we had a case from India of a patient on standard MDR TB regimen (Z, Cm, Lfx, Pto, Cs) who developed severe thrombocytopenia at 5 months of treatment initiation. Which could be the most likely drug? I would say Cm followed by Lfx. Any other suggestions or experiences? read more

Updated: 27 Feb, 2017
Replies: 0

Sputum vs Culture

Chaitali Nikam replied

Dear Ranjan, The correct sample & sample volumes are as follow: 500 ul of decontaminated sediment not sputum (500 ul of decontaminated specimen is prepared by concentration of 3-5 ml of sputum sample by NALC-NAOH method). About 1000ul of liquid culture; actually 1 ml of liquid culture; that showed positive ... read more

Updated: 26 Feb, 2017
Reply: 1

New community members

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Aung Phyo Khaing

Affiliated Organizations

World Health Organization - WHO

Work Locations

Myanmar

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Joshua Pulido

Affiliated Organizations

Hologic

Work Locations

United States

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Leonel Campos

Affiliated Organizations

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)

Work Locations

Brazil