Does the operational temperature of the Xpert machine affect the results outcome? why was it necessary to capture the operational temperature range in south africa?
Link leads to: http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673611604388.pdf?id=4d037fefcb72946c:-6ed9353d:12f9b9bdfb0:-17731303987864426
Summary: Feasibility, diagnostic accuracy, and effectiveness of decentralized use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. The Lancet 2011;377:1495-1505.
This clinical study evaluates the performance of the Xpert MTB/RIF in decentralized clinics in both peri-urban and urban areas. As the article notes, it is important to evaluate the diagnostic tool in the setting in which it will be used since initial evaluations carried out in ideal settings, such as reference laboratories, might be misleading. The results of this study demonstrate that the performance and accuracy of the Xpert MTB/RIF was similar to the initial clinical trial (NEJM reading above) confirming that the test can be used in low-resource settings for early and accurate diagnosis.
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Source: The Lancet
Keywords: diagnostics, Laboratory, Monitoring & Evaluation, Publications & Research