Mathilde Jachym

Recent Contributions

Reply to [ARCHIVED] Anti-TB Drugs and Arrhythmia: Theoretical Concern or Real Risk?

July 9, 2015
Thank you Michael Rich for your comment. I'm not sure a small daily supplementation of K+ or Ca++ would be a good idea without checking the serum levels. Linezolid is known to provide hyper kaliemia and I have 2 patient without renal impairment or adrenal insufficiency who experienced hyper kaliemia. ...

Reply to [ARCHIVED] Anti-TB Drugs and Arrhythmia: Theoretical Concern or Real Risk?

July 7, 2015
"How should cardiotoxic anti-TB drugs be combined into treatment regimens?" We try to avoid to combine cardiotoxic anti TB drugs. Some time there is no option because of the number of resistance on DST. The strategy is to have always 3 or 4 effective drugs Use Levofloxacine instead of Moxifloxacine. ...

Reply to [ARCHIVED] Anti-TB Drugs and Arrhythmia: Theoretical Concern or Real Risk?

July 6, 2015
Bedaquiline belongs to a new class of antituberculosis drug and has been approved by the US Food and Drug administration and the European Medicine Agency for the treatment of XMDR TB. The promising results of the first studies are counterbalanced by a worrying imbalance in the number of deaths found ...

Reply to RIF registant case detected by GeneXpert MTB/RIF found RIF sensitive by MGIT960

June 21, 2015
Gene xpert find mutations on the rpoB gene. The most frequent mutation occurs on the locus 531 and lead to rifampicine high level of resistance. Therefore Gene XPERT has a good specificity, but sometimes the resistance revealed by Gene Xpert is on another location e.i. 516. This mutation is not ...


Recent Recommendations

"[ARCHIVED] Anti-TB Drugs and Arrhythmia: Theoretical Concern or Real Risk?"

Anti-TB Drugs and Arrhythmia: Theoretical Concern or Real Risk?

"[ARCHIVED] Anti-TB Drugs and Arrhythmia: Theoretical Concern or Real Risk?"

Anti-TB Drugs and Arrhythmia: Theoretical Concern or Real Risk?