Tom Yates

Recent Contributions

Reply to Shorter MDR TB regimen

July 26, 2019
Dear Dr Dutt, I liked the following articles on the need for RCTs in MDR TB and the specific challenges in undertaking these important studies ... https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002767 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30215-4/fulltext

Reply to Shorter MDR TB regimen

July 26, 2019
I think Kelly Dooley is looking into the role of high dose INH in MDR patients with both inhA and katG mutations. Regards the short course regimens, it is worth noting the mortality signal in people with HIV co-infection in STREAM 1 ... [image: image.png] Sadly, guidelines moving ahead of ...

Reply to A game-changer in TB prevention!

Aug. 4, 2018
In the UK, we routinely use three months of rifampicin/isoniazid (Rifinah) to treat LTBI.

WHO Facility Checklist

July 31, 2018
Dear colleagues, Does anyone know whether this Checklist for Periodic Evaluation of TB Infection Control in Health-Care Facilities <http://www.who.int/tb/areas-of-work/preventive-care/checklist_for_periodic_evaluation_of_tb_infection_control_in_health_facilities.pdf> is the most up to date version? The copyright is dated 2015 and it refers to documents from 2009, 2012, 2014 and 2015. If this is the most recent document, does ...

Accuracy of DST and mortality

July 20, 2018
Dear all, I thought I would share this important preprint by Matthias Egger and team... https://www.biorxiv.org/content/early/2018/07/18/370056 They found limited agreement between DST results performed locally and those performed in a reference lab. Discordance was clearly of clinical importance with patients treated with inappropriate regimens experiencing markedly higher mortality. What does ...


Recent Recommendations

None at this time.